Anesthesia with hot peppers
Capsaicin is useful to produce anesthesia without paralysis associated with the majority of local anesthesia, according to us researchers Harga Cellmaxx
A substance derived from the hot peppers, capsaicin, could revolutionize the anaesthetic techniques, since it reduces the sensitivity without affecting the motor part. This technique could be particularly useful in situations in which are interested in suppressing pain while preserving functions motor, as in the case of deliveries. In addition, experts meeting at the annual Conference of the American Society of Anesthesiologists, point to capsaicin and nicotine as good tools to relieve postoperative pain.
Marijuana, nicotine and toxins of snails and fish are some of the natural elements from which new drugs are obtained. Now, experts of medicine from Harvard University, in the United States, conclude that the combination of a molecule that acts from the inside of the neuron with capsaicin in chillies, can block pain and produce anesthesia. In the research, carried out in rats, capsaicin along with a derivative of lidocaine, commonly used local anesthetic was administered. The injections made effect in 30 minutes and the pain relief lasted several hours.
The study, published recently in the journal ‘Nature’, reveals that the capsaicin acts as a facilitator for a derivative of lidocaine, which acts by blocking sodium (QX-314) channels, can penetrate into the neurons. Conventional local anesthesia acts globally, both at the level of sensitivity and movement, resulting in numbness and paralysis, as it happens after a dental procedure.
This new type of anesthesia acts only at the level of sensitivity without altering the motor function by what could be especially useful in those cases in which want to block pain, preserving the motor functions, as in the case of deliveries. According to Clifford Woolf, of Massachusetts General Hospital, the new method could transform surgery as ether did in his time. Also, was optimistic with the possibility that in two or three years the first tests carried out on human beings. The properties of capsaicin were already known and used as a local anesthetic in ointments to treat herpes zoster.
Capsaicin and nicotine
Capsaicin already is used as a local anesthetic in ointments to treat herpes zoster
Capsaicin applied locally, and nicotine patches alleviate pain after surgery, according to pray two studies presented at the annual meeting of the American Society of Anesthesiologists, recently conducted. In one of them, made in Copenhagen, applied 1000 micrograms of capsaicin directly on the wound of 20 patients who underwent hernia surgery. Comparing the degree of postoperative pain with a group treated with placebo control. The results were favorable for patients in the capsaicin group, who demonstrated less pain during the three days following surgery.
In other research was administered, 90 men non-smoking prior to prostate surgery, a 7 milligram nicotine patch or an identical free nicotine patch to be operated. After the surgery, each patient could control the pain with a drip of morphine. The men who received the nicotine patch had less need for morphine during the 24 hours following surgery than men who had the patch without the alkaloid.
The researchers noted that the nicotine seemed to relieve pain without causing narcotic side effects associated with morphine. Nausea were the only relevant side effect though, according to the authors of the study, they could minimize managing anti-Emetic drugs before the intervention. «Nicotine use in perioperative analgesia also needs studied in smokers, who probably will not suffer the side effects of nausea,» said Ashraf Habib, lead author and associate professor of Anesthesiology from Medical Center Duke University, during the Congress.
Nicotine patches are used for some time in the smoking cessation and some studies already had pointed it useful in relieving the pain. In one of them nicotine nasal spray was administered to women who had been a hysterectomy, with good results, although the mechanism by which nicotine possesses analgesic effect, since there are receivers of this substance both in the central nervous system and the peripheral is unknown. Use, in short periods of time, it is not addictive, according to Habib pointed out.